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Lysine

It is not synthesized in the animal. It is essential for growth. In microorganisms and in plants, the lysine is synthesized. Lysine is ketogenic amino acid. The ultimate product of lysine catabolism is acetoacetic acid. This nutrient was first isolated in 1889 from casein.

Lysine is an essential amino acid in the production of carnitine, which helps to convert fatty acids into energy and also helps to maintain the blood cholesterol in the human beings. It is also an important amino acid for growth. Lysine appears to help the body absorb and conserve calcium and it plays an important role in the formation of collagen, a substance important for bones and connective tissues including skin, tendon, and cartilage.

Sources of lysine:

Good sources of lysine are foods rich in protein including meat (specifically red meat, pork, and poultry), cheese (particularly parmesan), certain fish (such as cod and sardines), nuts, eggs, soybeans (particularly tofu, isolated soy protein, and defatted soybean flour), spirulina, and fenugreek seed.


For vegetarians, legumes (beans, peas and lentils) are the best sources of lysine.

Benefits of lysine:

It is required for growth and bone development in children, as it helps in the absorption of calcium and also maintains the correct nitrogen balance in the body and to prevent obesity.

Furthermore it is needed to produce antibodies, hormones, enzymes, collagen formation as well as repair of tissue.

It is also essential for the patients recovering from injuries and recovery after operations as it helps in the building of muscle proteins.

Lysine also helps to maintain the healthy blood vessels.

It also seems to assist in fighting herpes and cold sores.

Lysine is an essential amino acid in the production of carnitine, which helps to convert fatty acids into energy and also helps to maintain the blood cholesterol.

L-lysine can be used to treat mouth and genital lesions caused by herpes simplex virus as well as shingles caused by herpes zoster viruses.

Certain forms of lysine bound to anti-inflammatory medications may help relieve the pain following an episiotomy (a procedure performed during labor that involves cutting the vaginal area to enlarge the vaginal opening and facilitate delivery). These forms of lysine may also relieve migraine headaches and painful periods.

Deficiency symptoms of lysine

Deficiency of lysine in the diet can lead to the formation of kidney stones and other health related problems may develop including fatigue, nausea, dizziness, loss of appetite, agitation, bloodshot eyes, slow growth, anemia, and reproductive disorders.

As it helps in the absorption of calcium so deficiency of lysine can lead to defective bone development.

Generally, only vegetarians who follow a macrobiotic diet and certain athletes involved in frequent vigorous exercise are at risk for lysine deficiency

Symptoms of high intake

High intake of lysine may lead to the formation of gallstones and an elevation of cholesterol. But it is not proved in the human beings as yet.

Diarrhea and stomach cramps may be indicative in high dosage, but these are not consistent symptoms.

Who needed more?

Athletes, burn patients and people suffering from herpes and cold sores may need more lysine.

Older people could also require more lysine, as one study found older men required more of this nutrient than younger men.

Daily requirements

The daily requirement of lysine for different age groups is given below:

Pediatric

Birth to 4 months: 103 mg per kilogram of body weight per day

Children 5 months to 2 years: 69 mg per kilogram of body weight per day

Children 3 to 12 years: 44 mg per kilogram of body weight per day

Adult

13 and older: 12 mg per kilogram of body weight per day

Some experts suggest that adults may need up to 30 mg per kilogram of body weight per day.

Adults with herpes simplex should follow these guidelines:

To treat symptoms: 3,000 – 9,000 mg per day in divided doses

To prevent recurrences: 500 – 1,500 mg per day

Other information

Individuals with cardiovascular disease and those with elevated cholesterol and/or triglyceride levels should consult a medical practitioner before taking lysine supplements .

There are no reports in the scientific literature to suggest that lysine interacts with any conventional medications.

Lysine is involved in the browning reaction, or carmelization, in foods such as pastries, doughnuts, cookies and cereals. In this process, lysine and sugar stick together in a way that makes lysine difficult for the body to absorb. As a result, a diet high in cereals and baked goods, especially those that contain a lot of simple sugars, can result in low lysine intake.


 

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Comments

I once read/heard that almonds can cause Lysine deficiency in some people. Is this correct? I have sores aound the outside of my lips and in the corners of my mouth, could this be a sign of deficiency? Thanks. :-)
#1 - rose - 06/17/2008 - 09:46
When i was nervous or stress the herpes appear around my eyes (external) i was suffering this for 20 years.

Do you think that Lysine is the correct remedy?

Thank you for your comment.
#2 - vivi - 07/30/2008 - 17:32
I'm health freak but when i eat oranges, drink oranges or anything with substantial citrusy items i would have all these outer lip bumps and it's painful. What do i need to rectify this issue.
I would greatly appreciate your input to this matter.
#3 - Bebe - 01/05/2009 - 10:23
Lysine has kept me to get a minimum of cold sores. Since I started taking it I only get about one a year. Before up to 5. I take 2 tablets 1000 mg per day.
#4 - Benny - 01/18/2009 - 20:51
For anyone else that reads this, I wanted to answer the question posted above directlyabout almonds. Almonds (and other nuts) do not cause a deficiency; rather, they can contribute to a deficiency in a diet which already has a low lysine intake.

The reason for this is that all nuts contain high levels of arginine. Arginine and lysine compete with one another for uptake by the body. Therefore if you eat nuts, and your lysine levels are already low, you are increasing your arginine intake without increasing your lysine intake. The ratio of arginine:lysine increases in favor of arginine. This does resemble a deficiency.

If you increase your lysine intake at the same time as you increase your arginine intake, then you are raising the levels of both amino acids, which is generally fine (unless you have HSV and need to avoid arginine completely). If you need to avoid arginine, do not eat almonds, other nuts, or other foods containing arginine.

#5 - Bowman - 12/18/2009 - 10:57
How many nuts or how many legumes does one need to consume to achieve the benefits of arginine if one works out-cardio 4 times per week one hour per session and resistance 3 times per week 1/2 hour per session?
#6 - BFC - 01/05/2010 - 05:42
I have gotten cold sores since I was 5yrs old. Taking Lysine has helped a lot with healing time as well as outbreaks. I would suggest that anyone plagued with cold sores take lysine on a daily basis. It really does help!
#7 - LIL - 02/05/2010 - 13:18
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